{"id":125591,"date":"2020-04-23T18:08:26","date_gmt":"2020-04-23T15:08:26","guid":{"rendered":"http:\/\/epochtimestr.com\/?p=125591"},"modified":"2020-04-23T18:08:29","modified_gmt":"2020-04-23T15:08:29","slug":"prof-dr-ercument-ovalidan-23-nisan-mujdesi","status":"publish","type":"post","link":"https:\/\/epochtimestr.com\/index.php\/prof-dr-ercument-ovalidan-23-nisan-mujdesi","title":{"rendered":"Prof. Dr.Erc\u00fcment Oval\u0131&#8217;dan 23 Nisan M\u00fcjdesi"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/epochtimestr.com\/wp-content\/uploads\/2011y\/EWSri9yVcAMS4HB-600x341.jpg\" alt=\"\" class=\"wp-image-125592\" width=\"587\" height=\"333\" srcset=\"https:\/\/epochtimestr.com\/wp-content\/uploads\/2011y\/EWSri9yVcAMS4HB-600x341.jpg 600w, https:\/\/epochtimestr.com\/wp-content\/uploads\/2011y\/EWSri9yVcAMS4HB-300x171.jpg 300w, https:\/\/epochtimestr.com\/wp-content\/uploads\/2011y\/EWSri9yVcAMS4HB-150x85.jpg 150w, https:\/\/epochtimestr.com\/wp-content\/uploads\/2011y\/EWSri9yVcAMS4HB.jpg 680w\" sizes=\"(max-width: 587px) 100vw, 587px\" \/><figcaption>Foto :Prof.Dr.Erc\u00fcment Oval\u0131 Twitter Sayfas\u0131<\/figcaption><\/figure>\n\n\n\n<p> Prof. Dr. Erc\u00fcment Oval\u0131, Covid-19 a\u015f\u0131s\u0131nda geldikleri a\u015famay\u0131 sosyal medya hesab\u0131ndan payla\u015ft\u0131. <br \/><br \/>Prof. Dr. Erc\u00fcment Oval\u0131 : &#8220;Can\u0131m \u00fclkem art\u0131k Covid-19 a kar\u015f\u0131 a\u015f\u0131 geli\u015ftirebilen az say\u0131daki \u00fclkeler aras\u0131nda.&#8221;<\/p>\n\n\n\n<p>2 farkl\u0131 a\u015f\u0131 geli\u015ftirdiklerini ve laboratuvar testlerini tamamlad\u0131klar\u0131n\u0131 ifade eden Oval\u0131, &#8220;Covid-19 a kar\u015f\u0131 2 farkl\u0131 a\u015f\u0131 \u00fcretiminin laboratuvar k\u0131sm\u0131n\u0131 tamamlad\u0131k. S\u0131ra hayvan deneylerinde&#8221; dedi.\u00a0<br \/><br \/> Oval\u0131 a\u00e7\u0131klamalar\u0131nda \u015fu ifadeleri kulland\u0131:\u00a0 <br \/><br \/>&#8220;1.CORONA V\u0130R\u00dcS A\u015eISI HAYVAN DENEY\u0130 A\u015eAMASINA GELD\u0130!<br \/>COVID-19 \u0130naktif Vir\u00fcs A\u015f\u0131s\u0131; preklinik invitro test a\u015famas\u0131 tamamlanm\u0131\u015f olup, 24.04.2020 tarihinde hayvan \u00fczerinde deneylere ba\u015flanacakt\u0131r.<br \/>B\u00fct\u00fcn d\u00fcnya corona vir\u00fcs\u00fcne kar\u015f\u0131 a\u015f\u0131 geli\u015ftirme \u00e7abas\u0131nda. D\u00fcnyada \u00e7ok say\u0131da merkezde a\u015f\u0131 geli\u015ftirmek i\u00e7in \u00e7al\u0131\u015fmalar s\u00fcrd\u00fcr\u00fcl\u00fcyor. Bu a\u015f\u0131 ara\u015ft\u0131rmalar\u0131n\u0131n b\u00fcy\u00fck bir k\u0131sm\u0131, rekombinant yani sentetik a\u015f\u0131 \u00fcretimi \u00fczerine.A\u015f\u0131lar canl\u0131 vir\u00fcslerin kullan\u0131ld\u0131\u011f\u0131 atenue-inaktif veya vir\u00fcs\u00fcn sentetik par\u00e7alar\u0131ndan olu\u015fturulan rekombinant olmak \u00fczere iki y\u00f6ntemle haz\u0131rlan\u0131yor. \u0130naktif a\u015f\u0131lar, rekombinant a\u015f\u0131lardan \u00e7ok daha h\u0131zl\u0131 haz\u0131rlanabiliyor, viral mutasyonel de\u011fi\u015fikliklerden daha az etkileniyor ve daha uzun s\u00fcre etkin kullan\u0131labiliyor. \u00d6te yandan dezavantajlar\u0131 da var; kitlesel olarak \u00e7ok y\u00fcksek say\u0131da \u00fcretilemiyor, daha y\u00fcksek maliyetli, vir\u00fcs\u00fc canl\u0131 olarak laboratuvarda \u00e7o\u011faltmak gerekti\u011fi i\u00e7in maksimum d\u00fczeyde g\u00fcvenlik uygulamalar\u0131 gerekiyor, ba\u011f\u0131\u015f\u0131kl\u0131k olu\u015fturma y\u00fczdesi rekombinant a\u015f\u0131lara g\u00f6re daha d\u00fc\u015f\u00fck.Acil m\u00fcdahalelerin hayat kurtarabilece\u011fi bu \u00f6zel s\u00fcre\u00e7te, inaktif a\u015f\u0131n\u0131n olumlu taraflar\u0131na odaklanmak ve k\u0131sa d\u00f6nem avantajlar\u0131n\u0131 g\u00f6z \u00f6n\u00fcne almak gerekiyor. Y\u00fcksek say\u0131da \u00fcretilebilecek rekombinant a\u015f\u0131lar geli\u015ftirilene kadar, do\u011fas\u0131 gere\u011fi az miktarda \u00fcretilebilen inaktif a\u015f\u0131lar, \u00f6zellikle risk alt\u0131ndaki sa\u011fl\u0131k personelini, ileri ya\u015fl\u0131lar\u0131 ve yine kanser, ast\u0131m gibi ek hastal\u0131klar\u0131 bulunan risk alt\u0131ndaki ki\u015fileri koruyacak say\u0131da \u00fcretilebilir ve \u00e7ok \u00f6nemli bir yarar sa\u011flanabilir.\u00a0Biz, T\u00dcB\u0130TAK\u2019\u0131n destek verdi\u011fi COVID-19 inaktif vir\u00fcs a\u015f\u0131s\u0131 \u00e7al\u0131\u015fmam\u0131zda \u00fcretimi tamamlayarak hayvan deneylerinin yap\u0131laca\u011f\u0131 noktaya geldik. Hayvan deneylerinden sonra Faz-1 \u00e7al\u0131\u015fmalar\u0131 ba\u015fl\u0131yor, g\u00f6n\u00fcll\u00fclerde 3 hafta s\u00fcren yan etki ve antikor olu\u015fturma a\u00e7\u0131lar\u0131ndan de\u011ferlendirme yap\u0131l\u0131yor. Sonras\u0131nda daha geni\u015f bir pop\u00fclasyonda a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131 devam ediyor, yeterli g\u00fcvenlik ve etkinlik elde edildikten sonra yine \u00e7al\u0131\u015fma daha da geni\u015fletilebiliyor\u2026 \u0130deal ko\u015fullarda t\u00fcm bunlar, ortalama 3 ayda sonu\u00e7lanabilir. T\u00fcm bu a\u015famalar, Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019n\u0131n onay s\u00fcreciyle ger\u00e7ekle\u015fiyor. Peki, ba\u015far\u0131l\u0131 olunamazsa?&#8230; Pek \u00e7ok bilimsel ara\u015ft\u0131rman\u0131n ba\u015f\u0131na geldi\u011fi gibi, hayvan deneylerinde ya da sonras\u0131nda istenmeyen bir etki ile kar\u015f\u0131la\u015fabiliriz, bu durumda yine laboratuvara girer, yine \u00e7al\u0131\u015f\u0131r\u0131z.<br \/><br \/>2.K\u00d6K H\u00dcCRE \u00c7ALI\u015eMASI: 7 HASTA \u00dcZER\u0130NDE ARA\u015eTIRMA YAPILDI<br \/>COVID-19 Tedavisinde Mezenkimal K\u00f6k H\u00fccrenin Etkinli\u011fi; Faz II Klinik \u00c7al\u0131\u015fma olarak Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019na sunulmu\u015f olup, m\u00fcnferit hastalar i\u00e7in bakanl\u0131\u011f\u0131n izniyle uygulama yap\u0131lmaktad\u0131r. Kontrol grubuyla birlikte giden standardize \u00e7al\u0131\u015fma i\u00e7in proje onay\u0131na ihtiya\u00e7 duyulmaktad\u0131r. COVID-19 hastal\u0131\u011f\u0131n\u0131n tedavisinde mezenkimal k\u00f6k h\u00fccre uygulamas\u0131 yap\u0131labiliyor. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 tedavi rehberinde de yer almaktad\u0131r.\u00a0 Bu ek tedavi \u015fekli konusundaki klinik g\u00f6zlemlerimize g\u00f6re; uygun endikasyonla (ileri hastal\u0131k, ent\u00fcbe hasta) k\u00f6k h\u00fccre uygulanan 7 hastada iyi sonu\u00e7lar elde ettik. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019na yap\u0131lm\u0131\u015f ba\u015fvurumuz onayland\u0131\u011f\u0131 takdirde kontrol grubuyla beraber bilimsel bir veriye ula\u015fmak i\u00e7in klinik \u00e7al\u0131\u015fmay\u0131 ba\u015flataca\u011f\u0131z.<br \/><br \/>3.\u0130MM\u00dcN PLAZMA: HER KAN GRUBUNA UYUMLU B\u0130R PLAZMA \u00dcRETT\u0130K<br \/>ACU-IP1.0 (Ba\u011f\u0131\u015f\u0131k Konsantre\/Patojen Free Plazma); \u00fcretimin yap\u0131labilmesi i\u00e7in t\u00fcm \u015fartlar olu\u015fturulmu\u015ftur. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019n\u0131n COVID-19 \u0130mm\u00fcn Plazma kullan\u0131m\u0131yla ilgili genelgesi sonras\u0131 bu \u00fcr\u00fcn de kullan\u0131ma girmi\u015f olup, laboratuvarlar\u0131m\u0131zda \u00fcretilmektedir. Faz II Klinik \u00e7al\u0131\u015fma i\u00e7in onay beklenmektedir. T\u00dcB\u0130TAK taraf\u0131ndan desteklenen bu ara\u015ft\u0131rma projesi, hastal\u0131\u011f\u0131 yenerek ba\u011f\u0131\u015f\u0131kl\u0131k kazanm\u0131\u015f ki\u015filerden kan al\u0131nmas\u0131 ile elde edilecek vir\u00fcs spesifik antikorlar\u0131n toplanmas\u0131 ve bunlar\u0131n yeni hastalar\u0131n tedavisinde kullan\u0131lmas\u0131na dayan\u0131yor. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131, COVID-19 tan\u0131s\u0131 al\u0131p iyile\u015fen ki\u015filerden al\u0131nan imm\u00fcn plazman\u0131n i\u00e7erdi\u011fi antikorlar nedeniyle hastalar\u0131n tedavisinde kullan\u0131labilece\u011fini onaylam\u0131\u015ft\u0131r. An itibariyle hastalarda kullan\u0131lacak olan imm\u00fcn plazman\u0131n haz\u0131rlanmas\u0131 laboratuvarlar\u0131m\u0131zda en uygun \u015fartlarda ger\u00e7ekle\u015ftiriliyor. Birden fazla ki\u015fiden al\u0131narak havuzlanan plazma; t\u00fcm vir\u00fcs ve bakterilerden ar\u0131nd\u0131r\u0131l\u0131yor, konsantre ediliyor, i\u00e7erdi\u011fi antikor d\u00fczeyi ve \u00e7e\u015fitlili\u011fi, ayr\u0131ca bunlar\u0131n vir\u00fcs n\u00f6tralizasyon kapasitesi de \u00f6l\u00e7\u00fclebiliyor ve standart d\u00fczeye getiriliyor (\u00fcr\u00fcnden \u00fcr\u00fcne farkl\u0131l\u0131k olmuyor). Haz\u0131rlanan plazmadaki antikorlar\u0131n titre edilerek miktarlar\u0131n\u0131n bilinmesi ve vir\u00fcs\u00fc n\u00f6tralize etme kapasitesinin \u00f6l\u00e7\u00fclebilmesi, plazma haz\u0131rl\u0131k a\u015famas\u0131nda \u00e7ok \u00f6nemlidir. Ayr\u0131ca kan grubu uyumu sorunu olu\u015fturmayacak \u015fekilde haz\u0131rlanmaktad\u0131r. \u0130mm\u00fcn plazman\u0131n hastalara y\u00f6nelik klinik uygulamalar\u0131 da devam ediyor.<br \/><br \/>4.COVID-19 V\u0130R\u00dcS SPES\u0130F\u0130K T-LENFOS\u0130TLER: V\u0130R\u00dcSLE SAVA\u015eACAK T LENFOS\u0130TLER HAZIRLIYORUZ!<br \/>COVID-19 Spesifik T-lenfositler; \u00fcretimi tamamlanm\u0131\u015f olup Faz II Klinik \u00e7al\u0131\u015fma i\u00e7in T\u00dcSEB\u2019e destek ba\u015fvurusu yap\u0131lm\u0131\u015ft\u0131r.\u00a0T-Lenfositler insanlarda ba\u011f\u0131\u015f\u0131kl\u0131ktan sorumlu sava\u015f\u00e7\u0131 h\u00fccrelerdir. Laboratuvar ortam\u0131nda da baz\u0131 \u00f6zel y\u00f6ntemlerle vir\u00fcs\u00fcn tipine \u00f6zg\u00fcn olarak haz\u0131rlanan bu h\u00fccreler, bug\u00fcn diren\u00e7li viral enfeksiyonlar\u0131n (EBV, CMEV, BK, AV) tedavisinde t\u00fcm d\u00fcnyada \u00e7e\u015fitli merkezlerde uzun s\u00fcredir ba\u015far\u0131 ile kullan\u0131l\u0131yor. \u00d6zellikle kanser, ba\u011f\u0131\u015f\u0131kl\u0131k yetmezli\u011fi ya da ba\u011f\u0131\u015f\u0131kl\u0131k bask\u0131lay\u0131c\u0131 tedavi g\u00f6ren hastalar i\u00e7in uygulan\u0131l\u0131yor. G\u00fcn\u00fcm\u00fczde ise corona vir\u00fcse kar\u015f\u0131 sava\u015fmak i\u00e7in yine laboratuvar \u015fartlar\u0131nda haz\u0131rlanan T-lenfositlerin klinik uygulamalarda ba\u015far\u0131l\u0131 olabilece\u011fi \u00f6ng\u00f6r\u00fcl\u00fcyor. Corona vir\u00fcs\u00fcne \u00f6zg\u00fcn \u00fcretimini tamamlad\u0131\u011f\u0131m\u0131z T lenfositlerin COVID-19 hastalar\u0131n\u0131n tedavisinde etkinli\u011fini kan\u0131tlamak \u00fczere T\u00dcSEB\u2019e destek ba\u015fvurusu yap\u0131lm\u0131\u015f olup, Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019na da klinik ara\u015ft\u0131rma ba\u015fvurusu yap\u0131lacakt\u0131r.<br \/><br \/>5.DORNAZ ALFA \u00c7ALI\u015eMASI: KL\u0130N\u0130K G\u00d6ZLEMLER DENEMEYE DEVAM ED\u0130LMES\u0130 GEREKT\u0130\u011e\u0130N\u0130 G\u00d6STER\u0130YOR! <br \/>COVID-19 Tedavisinde Dornaz Alfa\u2019n\u0131n etkinlik ve g\u00fcvenlilik \u00e7al\u0131\u015fmas\u0131; T\u00fcm laboratuvar s\u00fcre\u00e7leri tamamlanm\u0131\u015f olup, Faz II Klinik \u00e7al\u0131\u015fma i\u00e7in T\u00dcSEB\u2019e ba\u015fvurusu yap\u0131lm\u0131\u015ft\u0131r. In vitro \u015fartlarda (laboratuvar ortam\u0131nda) beyaz k\u00fcrelerin olu\u015fturdu\u011fu jelimsi tabakay\u0131 s\u00fcratle eritebildi\u011fini g\u00f6zlemledi\u011fimiz bu ilac\u0131 kullanan kistik fibrozisli hastalarda da COVID-19 enfeksiyonun daha hafif seyretmesi nedeniyle, standart tedaviye diren\u00e7li 3 hastada uygulama sonucu iyile\u015fme oldu\u011funu g\u00f6rd\u00fck. Bu bulgular daha \u00f6nce laboratuvar ortam\u0131ndaki bulgulara uyumlu olarak COVID-19hastalar\u0131n\u0131n akci\u011ferlerinde geli\u015fen solunum zorlu\u011funun kontrol edilebildi\u011fini g\u00f6zlemledik.<br \/>Sonu\u00e7 olarak bu ilac\u0131n tedavide \u00f6zellikle erken d\u00f6nemde (ent\u00fcbasyon \u00f6ncesi) uygulanabilirli\u011fi ile ilgili olarak T\u00dcSEB\u2019e destek ba\u015fvurusu yap\u0131lm\u0131\u015f olup, Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019na da klinik ara\u015ft\u0131rma ba\u015fvurusu yap\u0131lacakt\u0131r.&#8221;<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><br \/><\/p>\n\n\n\n<p> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. Dr. Erc\u00fcment Oval\u0131, Covid-19 a\u015f\u0131s\u0131nda geldikleri a\u015famay\u0131 sosyal medya hesab\u0131ndan payla\u015ft\u0131. Prof. Dr. Erc\u00fcment Oval\u0131 : &#8220;Can\u0131m \u00fclkem art\u0131k Covid-19 a kar\u015f\u0131 a\u015f\u0131 geli\u015ftirebilen az say\u0131daki \u00fclkeler aras\u0131nda.&#8221; 2 farkl\u0131 a\u015f\u0131 geli\u015ftirdiklerini ve laboratuvar testlerini tamamlad\u0131klar\u0131n\u0131 ifade eden Oval\u0131, &#8220;Covid-19 a kar\u015f\u0131 2 farkl\u0131 a\u015f\u0131 \u00fcretiminin laboratuvar k\u0131sm\u0131n\u0131 tamamlad\u0131k. S\u0131ra hayvan deneylerinde&#8221; dedi.\u00a0 Oval\u0131 [&hellip;]<\/p>\n","protected":false},"author":13971,"featured_media":125592,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":"","_yoast_wpseo_focuskw_text_input":""},"categories":[1,37],"tags":[7251],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prof. Dr.Erc\u00fcment Oval\u0131&#039;dan 23 Nisan M\u00fcjdesi - The Epoch Times TR<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/epochtimestr.com\/index.php\/prof-dr-ercument-ovalidan-23-nisan-mujdesi\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prof. Dr.Erc\u00fcment Oval\u0131&#039;dan 23 Nisan M\u00fcjdesi - The Epoch Times TR\" \/>\n<meta property=\"og:description\" content=\"Prof. Dr. Erc\u00fcment Oval\u0131, Covid-19 a\u015f\u0131s\u0131nda geldikleri a\u015famay\u0131 sosyal medya hesab\u0131ndan payla\u015ft\u0131. Prof. Dr. Erc\u00fcment Oval\u0131 : &#8220;Can\u0131m \u00fclkem art\u0131k Covid-19 a kar\u015f\u0131 a\u015f\u0131 geli\u015ftirebilen az say\u0131daki \u00fclkeler aras\u0131nda.&#8221; 2 farkl\u0131 a\u015f\u0131 geli\u015ftirdiklerini ve laboratuvar testlerini tamamlad\u0131klar\u0131n\u0131 ifade eden Oval\u0131, &#8220;Covid-19 a kar\u015f\u0131 2 farkl\u0131 a\u015f\u0131 \u00fcretiminin laboratuvar k\u0131sm\u0131n\u0131 tamamlad\u0131k. 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