{"id":155552,"date":"2024-12-02T13:49:32","date_gmt":"2024-12-02T10:49:32","guid":{"rendered":"https:\/\/epochtimestr.com\/?p=155552"},"modified":"2024-12-02T13:49:34","modified_gmt":"2024-12-02T10:49:34","slug":"neredeyse-tum-enfeksiyonlari-teshis-edebilen-test","status":"publish","type":"post","link":"https:\/\/epochtimestr.com\/index.php\/neredeyse-tum-enfeksiyonlari-teshis-edebilen-test","title":{"rendered":"Neredeyse T\u00fcm Enfeksiyonlar\u0131 Te\u015fhis Edebilen Test"},"content":{"rendered":"\n

Bilim insanlar\u0131 neredeyse t\u00fcm enfeksiyonlar\u0131 te\u015fhis edebilen bir test geli\u015ftirdi.<\/p>\n\n\n\n

Yeni bir genom testi, tek bir analizle birden fazla patojeni tespit edebiliyor. B\u00f6ylece, hastal\u0131klar\u0131n daha h\u0131zl\u0131 ve daha do\u011fru te\u015fhisi m\u00fcmk\u00fcn olabilecek.<\/p>\n\n\n

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Bilim insanlar\u0131, tek bir analizle birden fazla patojeni te\u015fhis edebilen yeni bir genom testi geli\u015ftirdiler. (Foto\u011fraf: Geralt, Pixabay)<\/em><\/figcaption><\/figure><\/div>\n\n\n

Ara\u015ft\u0131rmac\u0131lar, insan v\u00fccudundaki hemen hemen her bula\u015f\u0131c\u0131 patojeni te\u015fhis edebilen bir genom testi geli\u015ftirdiler.<\/p>\n\n\n\n

Kaliforniya \u00dcniversitesi-San Francisco\u2019da (UCSF) on y\u0131l s\u00fcren ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131 12 Kas\u0131m\u2019da Nature Medicine\u2019da<\/a> yay\u0131mland\u0131. Makaleye g\u00f6re test, n\u00f6rolojik enfeksiyonlar\u0131n te\u015fhisinde y\u00fczde 86\u2019l\u0131k bir ba\u015far\u0131 oran\u0131 g\u00f6steriyor.<\/p>\n\n\n\n

Ayr\u0131ca ayn\u0131 g\u00fcn Nature Communications\u2019da<\/a> yay\u0131nlanan bir makale daha var. Makaleye g\u00f6re bu test, solunum yolu vir\u00fcslerini tespit etmede y\u00fczde 90\u2019\u0131n \u00fczerinde do\u011fruluk g\u00f6steriyor. Mevcutta uygulanan alt\u0131n standart tan\u0131 testleri, polimeraz zincir reaksiyonu (PCR) testi olarak biliniyor.<\/p>\n\n\n\n

ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA<\/a>), yeni testi yak\u0131n zamanda onaylad\u0131. Bu test, menenjit ve ensefalit gibi n\u00f6rolojik enfeksiyonlar\u0131n tedavisine \u00f6nemli katk\u0131lar sa\u011flama potansiyeline sahip. Ayr\u0131ca yeni viral pandemi tehditlerinin tespitini de h\u0131zland\u0131rabilecek.<\/p>\n\n\n\n

Teknoloji Nas\u0131l \u00c7al\u0131\u015f\u0131yor<\/strong><\/h3>\n\n\n\n

Di\u011fer testlerin \u00e7o\u011fu bir seferde yaln\u0131zca bir veya birka\u00e7 patojeni tespit edebiliyor. Ancak bu yeni test, bir numunedeki genetik materyali analiz ederek, mevcut t\u00fcm patojenleri tespit edebiliyor.<\/p>\n\n\n\n

Ayr\u0131ca bu test ile hastal\u0131\u011f\u0131n \u015fiddetini de tahmin etmek m\u00fcmk\u00fcn. \u00dcstelik hedef patojeni h\u0131zla daraltmak i\u00e7in numunedeki \u00e7e\u015fitli patojenlerin miktar\u0131n\u0131 da \u00f6l\u00e7ebiliyor.<\/p>\n\n\n\n

Teknoloji ilk olarak, beyin ve omurili\u011fi \u00e7evreleyen s\u0131v\u0131 olan beyin omurilik s\u0131v\u0131s\u0131n\u0131 (BOS), metagenomik yeni nesil dizileme (mNGS) ad\u0131 verilen g\u00fc\u00e7l\u00fc bir genom dizileme tekni\u011fi kullanarak analiz etmek i\u00e7in geli\u015ftirildi. Hem UCSF\u2019de hem de ABD\u2019deki di\u011fer hastanelerde, a\u00e7\u0131klanamayan n\u00f6rolojik semptomlar ya\u015fayan binlerce hastada uyguland\u0131.<\/p>\n\n\n\n

Nature Communications<\/a> dergisindeki makalede ara\u015ft\u0131rmac\u0131lar, solunum s\u0131v\u0131s\u0131nda zat\u00fcrreye neden olan patojenleri nas\u0131l tespit ettiklerini anlatt\u0131lar. Bunun i\u00e7in mNGS s\u00fcrecini nas\u0131l otomatikle\u015ftirdiklerini a\u00e7\u0131klad\u0131lar.<\/p>\n\n\n\n

Tek Testle Her \u015eeyi Kapsayan Bir \u00c7\u00f6z\u00fcm<\/strong><\/h3>\n\n\n\n

Bu yenilik, nadir veya bilinmeyen patojenler nedeniyle te\u015fhis konulamayan n\u00f6rolojik hastal\u0131klar i\u00e7in \u00f6nemli olabilir. Bilindi\u011fi gibi tan\u0131daki gecikmeler tedavi sonu\u00e7lar\u0131n\u0131 ciddi \u015fekilde etkileyebiliyor.<\/p>\n\n\n\n

Dr. Charles Chiu, UCSF\u2019de t\u0131bbi laboratuvar ve bula\u015f\u0131c\u0131 hastal\u0131klar profes\u00f6r\u00fc ve \u00e7al\u0131\u015fman\u0131n k\u0131demli yazar\u0131d\u0131r. \u00a0Chiu bir bas\u0131n a\u00e7\u0131klamas\u0131nda<\/a> \u201cTeknolojimiz, d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcn\u00fczden daha basit\u201d dedi. \u201cBirden fazla testi tek bir testle birle\u015ftirdik. B\u00f6ylece enfeksiyonlar\u0131 te\u015fhis ve tedavi etme s\u00fcrecinde en \u00e7ok zaman alan tahmin i\u015fini ortadan kald\u0131rd\u0131k.\u201d<\/p>\n\n\n\n

Neredeyse t\u00fcm enfeksiyonlar\u0131 te\u015fhis edebilen yeni test, tan\u0131t\u0131ld\u0131\u011f\u0131 g\u00fcnden bu yana, d\u00fcnyada ger\u00e7ek bir etki yaratt\u0131. ABD Wisconsin\u2019de dikkat \u00e7ekici bir vaka ger\u00e7ekle\u015fti. Gen\u00e7 bir \u00e7ocu\u011fun enfeksiyonu te\u015fhis edilemiyordu ve test h\u0131zl\u0131 sonu\u00e7lar \u00fcreterek sorunun \u00e7\u00f6z\u00fclmesine yard\u0131mc\u0131 oldu.<\/p>\n\n\n\n

UCSF ekibi 2016 ile 2023 y\u0131llar\u0131 aras\u0131nda yakla\u015f\u0131k 5.000 BOS \u00f6rne\u011fini analiz etti. Yeni test \u00f6rneklerin %14\u2019\u00fcnden fazlas\u0131n\u0131n enfekte oldu\u011funu tespit etti. Ayr\u0131ca patojenleri %86 oran\u0131nda te\u015fhis etti.<\/p>\n\n\n\n

Chiu bas\u0131n a\u00e7\u0131klamas\u0131nda \u201cmNGS testimiz n\u00f6rolojik enfeksiyonlarda di\u011fer t\u00fcm testlerden daha iyi performans g\u00f6steriyor\u201d dedi.<\/p>\n\n\n\n

Beklenen Geli\u015fmeler<\/strong><\/h3>\n\n\n\n

\u00d6zellikle solunum testleri alan\u0131nda teknoloji geli\u015fimi devam ediyor.<\/p>\n\n\n\n

Mevcut CSF testi 100\u2019den fazla ad\u0131m i\u00e7eriyor ve tamamlanmas\u0131 iki ila yedi g\u00fcn s\u00fcr\u00fcyor. Bunun yan\u0131 s\u0131ra yeni solunum testi \u00e7ok daha h\u0131zl\u0131 sonu\u00e7lar hedefliyor. Chiu \u201cT\u00fcm s\u00fcreci 12 ila 24 saat i\u00e7inde tamamlay\u0131p sonu\u00e7 almak amac\u0131yla yola \u00e7\u0131kt\u0131k\u201d dedi.<\/p>\n\n\n\n

Her iki \u00e7al\u0131\u015fman\u0131n bulgular\u0131 mNGS testinin, solunum yolu hastal\u0131klar\u0131n\u0131 te\u015fhis edebilen bir test olabilece\u011fini g\u00f6steriyor. Vir\u00fcs listesine, COVID-19\u2019a neden olan SARS-CoV-2 gibi pandemiye neden olma potansiyeline sahip vir\u00fcsler de d\u00e2hil. \u00dcstelik yeni test, \u00f6rnek \u00fczerinde az miktarda vir\u00fcs olsa bile, yakla\u015f\u0131k bir g\u00fcnde sonu\u00e7 veriyor.<\/p>\n\n\n\n

CSF ve solunum mNGS testleri yak\u0131n zamanda FDA\u2019dan \u00e7\u0131\u011f\u0131r a\u00e7an cihaz onay\u0131<\/a> alm\u0131\u015ft\u0131. Bu onay \u00fcreticilerin, cihaz\u0131n pazara sunulmadan \u00f6nceki inceleme a\u015famas\u0131nda ortaya \u00e7\u0131kan sorunlar\u0131 ele almak i\u00e7in, FDA uzmanlar\u0131yla birlikte \u00e7al\u0131\u015fmas\u0131na olanak tan\u0131yor.<\/p>\n\n\n\n

\n
<\/div>\n<\/div>\n\n\n\n

Yazan:<\/em> George Citroner, The Epoch Times<\/p>\n","protected":false},"excerpt":{"rendered":"

Bilim insanlar\u0131 neredeyse t\u00fcm enfeksiyonlar\u0131 te\u015fhis edebilen bir test geli\u015ftirdi. Yeni bir genom testi, tek bir analizle birden fazla patojeni tespit edebiliyor. B\u00f6ylece, hastal\u0131klar\u0131n daha h\u0131zl\u0131 ve daha do\u011fru te\u015fhisi m\u00fcmk\u00fcn olabilecek. Ara\u015ft\u0131rmac\u0131lar, insan v\u00fccudundaki hemen hemen her bula\u015f\u0131c\u0131 patojeni te\u015fhis edebilen bir genom testi geli\u015ftirdiler. Kaliforniya \u00dcniversitesi-San Francisco\u2019da (UCSF) on y\u0131l s\u00fcren ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131 […]<\/p>\n","protected":false},"author":12791,"featured_media":155553,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"te\u015fhis edebilen","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Yeni bir genom testi, tek bir analizle birden fazla patojeni tespit edebiliyor. Hastal\u0131klar\u0131n daha h\u0131zl\u0131 ve daha do\u011fru te\u015fhisi m\u00fcmk\u00fcn.","_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":"","_yoast_wpseo_focuskw_text_input":""},"categories":[5,519,6909],"tags":[8449],"yoast_head":"\nNeredeyse T\u00fcm Enfeksiyonlar\u0131 Te\u015fhis Edebilen Test - The Epoch Times TR<\/title>\n<meta name=\"description\" content=\"Yeni bir genom testi, tek bir analizle birden fazla patojeni tespit edebiliyor. 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