{"id":172389,"date":"2026-10-01T09:24:28","date_gmt":"2026-10-01T06:24:28","guid":{"rendered":"https:\/\/epochtimestr.com\/?p=172389"},"modified":"2026-10-01T09:25:07","modified_gmt":"2026-10-01T06:25:07","slug":"kanser-vakalarinin-sekizde-biri-enfeksiyonlardan-kaynaklaniyor","status":"publish","type":"post","link":"https:\/\/epochtimestr.com\/index.php\/kanser-vakalarinin-sekizde-biri-enfeksiyonlardan-kaynaklaniyor","title":{"rendered":"Kanser Vakalar\u0131n\u0131n Sekizde Biri Enfeksiyonlardan Kaynaklan\u0131yor"},"content":{"rendered":"
\n
\"D\u00fcnya
D\u00fcnya genelindeki kanser vakalar\u0131n\u0131n 8’de 1’i enfeksiyonlardan kaynaklan\u0131yor. (G\u00f6rsel: PublicDomainPicture, Pixabay)<\/figcaption><\/figure><\/div>\n\n\n

Kanser risk fakt\u00f6rleri denildi\u011finde \u00e7o\u011fumuzun akl\u0131na ilk olarak sigara, g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 veya genetik yatk\u0131nl\u0131k gelir.<\/h2>\n\n\n\n

Kanser<\/a> risk fakt\u00f6rleri denildi\u011finde \u00e7o\u011fumuzun akl\u0131na ilk olarak sigara, g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 veya genetik yatk\u0131nl\u0131k gelir. Ancak t\u0131p d\u00fcnyas\u0131ndan gelen son veriler, gizli bir tehlikeyi g\u00f6zler \u00f6n\u00fcne seriyor. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc\u2019ne (DS\u00d6<\/a>) ba\u011fl\u0131 Uluslararas\u0131 Kanser Ara\u015ft\u0131rma Ajans\u0131’n\u0131n (IARC) yapt\u0131\u011f\u0131 yeni bir ara\u015ft\u0131rma, d\u00fcnya genelindeki kanser vakalar\u0131n\u0131n 8’de 1’inin enfeksiyonlardan kaynakland\u0131\u011f\u0131n\u0131 ortaya koydu.<\/p>\n\n\n\n

Sayg\u0131n t\u0131p dergisi The Lancet Oncology’de yay\u0131mlanan bu kapsaml\u0131 analiz, d\u00fcnya genelindeki 2,3 milyon yeni kanser vakas\u0131n\u0131n (t\u00fcm vakalar\u0131n yakla\u015f\u0131k %12’si) enfeksiyonlarla ba\u011flant\u0131l\u0131 oldu\u011funu g\u00f6steriyor<\/a>.<\/p>\n\n\n\n

Sinsi sabotajc\u0131lar h\u00fccreleri nas\u0131l ele ge\u00e7iriyor?<\/strong><\/p>\n\n\n\n

Uzmanlar, bu k\u00fcresel \u00e7al\u0131\u015fman\u0131n amac\u0131n\u0131n ge\u00e7mi\u015f y\u0131llarla k\u0131yaslama yapmak olmad\u0131\u011f\u0131n\u0131, aksine enfeksiyonlar\u0131 kontrol alt\u0131na alarak kanser oranlar\u0131n\u0131 nas\u0131l d\u00fc\u015f\u00fcrebilece\u011fimizi d\u00fcnyaya g\u00f6stermek oldu\u011funu vurguluyor. Peki, v\u00fccudumuza giren basit bir vir\u00fcs ya da bakteri nas\u0131l oluyor da \u00f6l\u00fcmc\u00fcl bir t\u00fcm\u00f6re d\u00f6n\u00fc\u015f\u00fcyor?
Kapsaml\u0131 ara\u015ft\u0131rmalar, bu gizemli ba\u011f\u0131n ard\u0131ndaki molek\u00fcler mekanizmalar\u0131 \u00e7\u00f6zd\u00fc. Mikroplar, v\u00fccudumuzu adeta birer “sabotajc\u0131” gibi ele ge\u00e7iriyor:<\/p>\n\n\n\n

Vir\u00fcsler DNA’ya s\u0131z\u0131yor: <\/strong>Vir\u00fcsler, sa\u011fl\u0131kl\u0131 bir h\u00fccrenin genetik kodunu de\u011fi\u015ftirerek onun kontrols\u00fczce b\u00fcy\u00fcmesini tetikliyor. Bunu ya h\u00fccrenin “imdat butonunu” kapatarak (h\u00fccrenin kendini yok etmesini engelleyerek) ya kendi DNA’s\u0131n\u0131 h\u00fccreye monte ederek ya da do\u011frudan kanser yap\u0131c\u0131 genleri (onkogen) enjekte ederek yap\u0131yorlar.<\/p>\n\n\n\n

Bakteriler ve parazitler “s\u00fcrekli stres” yarat\u0131yor:<\/strong> Mide \u00fclseriyle bilinen Helicobacter pylori bakterisi veya Sahra Alt\u0131 Afrika’da g\u00f6r\u00fclen parazitler (Schistosoma haematobium) vir\u00fcsler gibi DNA’ya do\u011frudan s\u0131zmak yerine daha dolayl\u0131 bir y\u00f6ntem se\u00e7iyor: Kronik \u0130ltihap. Dokularda y\u0131llar s\u00fcren bu amans\u0131z bask\u0131, hasar ve tahribat, h\u00fccrelerin en sonunda pes ederek kanserle\u015fmesine neden oluyor.<\/p>\n\n\n

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En fazla enfeksiyon kaynakl\u0131 kansere neden olan alt\u0131 etken i\u00e7in 2024 y\u0131l\u0131nda 100.000 ki\u015fi-y\u0131l ba\u015f\u0131na enfeksiyon kaynakl\u0131 kanserlerin ya\u015f s\u0131n\u0131r\u0131 indeksi.<\/figcaption><\/figure><\/div>\n\n\n

Kanser yap\u0131c\u0131 vir\u00fcslerin k\u00fcresel r\u00f6ntgeni<\/h3>\n\n\n\n

Ara\u015ft\u0131rma, kanser y\u00fck\u00fcne neden olan en tehlikeli patojenlerin co\u011frafi da\u011f\u0131l\u0131mlar\u0131n\u0131 ve yaratt\u0131klar\u0131 tehditleri tek tek de\u015fifre ediyor:<\/p>\n\n\n\n

HPV (\u0130nsan Papillomavir\u00fcs\u00fc) erkekleri de tehdit ediyor<\/strong><\/p>\n\n\n\n

HPV, \u00f6zellikle Sahra Alt\u0131 Afrika \u00fclkelerinde k\u00fcresel ortalaman\u0131n iki kat\u0131ndan fazla bir oranla kanserin ba\u015fl\u0131ca nedenlerinden biri. Rahim a\u011fz\u0131 kanserlerinin %100\u2019\u00fcn\u00fcn HPV\u2019ye ba\u011fl\u0131 oldu\u011fu kabul ediliyor. Bu vir\u00fcs\u00fcn 17 farkl\u0131 t\u00fcr\u00fc kanserojen olsa da, HPV 16 ve 18 tek ba\u015f\u0131na t\u00fcm rahim a\u011fz\u0131 kanserlerinin d\u00f6rtte \u00fc\u00e7\u00fcn\u00fc olu\u015fturuyor. Sekiz tehlikeli t\u00fcr ise vakalar\u0131n %95’inden sorumlu.<\/p>\n\n\n\n

Ezber bozan ger\u00e7ek, HPV sadece kad\u0131nlar\u0131 de\u011fil erkeklerde de a\u011f\u0131z, yutak, anal ve penis kanserlerini tetikliyor. \u00d6zellikle s\u00fcr\u00fc ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131ndan faydalanamayan ve HIV ile ya\u015fayan erkekler anal kanser a\u00e7\u0131s\u0131ndan en y\u00fcksek risk grubunda yer al\u0131yor.<\/p>\n\n\n\n

HBV, HCV ve yeni tehdit HDV (Hepatit Grubu)<\/strong><\/p>\n\n\n\n

Hepatit vir\u00fcslerine ba\u011fl\u0131 karaci\u011fer kanseri y\u00fck\u00fc en \u00e7ok Do\u011fu Asya, G\u00fcneydo\u011fu Asya ve Kuzey Afrika\u2019da yo\u011funla\u015f\u0131yor; \u00f6zellikle Mo\u011folistan ve M\u0131s\u0131r bu durumdan en a\u011f\u0131r darbeyi alan \u00fclkeler. \u00d6te yandan bilim insanlar\u0131, karaci\u011fer kanseri riskini katlayan Hepatit D (HDV) vir\u00fcs\u00fcne kar\u015f\u0131 da uyar\u0131yor. Ancak sevindirici olan \u015fu ki, Hepatit B’yi hedef alan \u00f6nlemler Hepatit D’yi de otomatik olarak engelliyor.<\/p>\n\n\n\n

EBV (Epstein-Barr Vir\u00fcs\u00fc) listede h\u0131zla t\u0131rman\u0131yor<\/h3>\n\n\n\n

\u00d6nceki tahminlere k\u0131yasla korkutucu bir s\u0131\u00e7rama yapan EBV, Hepatit C’yi geride b\u0131rakarak k\u00fcresel olarak kansere yol a\u00e7an en tehlikeli 4. enfeksiyon etkeni oldu. EBV’nin mide kanseri ve belirli lenfoma t\u00fcrlerindeki rol\u00fcne dair kan\u0131tlar giderek g\u00fc\u00e7leniyor. G\u00fcneydo\u011fu Asya’da \u00e7o\u011funlukla yutak (nazofarenks) kanserine yol a\u00e7arken, di\u011fer b\u00f6lgelerde mide kanserini tetikliyor.<\/p>\n\n\n\n

HIV ve kaposi sarkomu ortakl\u0131\u011f\u0131<\/strong><\/p>\n\n\n\n

Bu analiz, d\u00fcnyada HIV vir\u00fcs\u00fcn\u00fc enfeksiyon kaynakl\u0131 kanser y\u00fck\u00fc tahminlerine dahil eden ilk \u00e7al\u0131\u015fma olma \u00f6zelli\u011fini ta\u015f\u0131yor. HIV, asl\u0131nda di\u011fer kanser yap\u0131c\u0131 vir\u00fcslerin (HPV, EBV vb.) \u00f6n\u00fcndeki ba\u011f\u0131\u015f\u0131kl\u0131k duvar\u0131n\u0131 y\u0131karak kanser riskini katl\u0131yor. \u00d6zellikle nadir bir kanser t\u00fcr\u00fc olan Kaposi sarkomunun %71’i do\u011frudan HIV ile ba\u011flant\u0131l\u0131. Ayr\u0131ca gelecekte, yayg\u0131n bir s\u0131tma paraziti olan Plasmodium falciparum ile Burkitt lenfomas\u0131 aras\u0131ndaki olas\u0131 ba\u011flant\u0131lar\u0131n da listeye eklenmesi bekleniyor.<\/p>\n\n\n\n

Sadece kanser de\u011fil fel\u00e7ten k\u00f6rl\u00fc\u011fe kadar y\u0131k\u0131c\u0131 etkiler<\/h3>\n\n\n\n

Bilim insanlar\u0131 bu sinsi enfeksiyon etkenlerinin zarar\u0131n\u0131n sadece kanserle s\u0131n\u0131rl\u0131 kalmad\u0131\u011f\u0131n\u0131, teorik olarak \u00f6nlenebilecek di\u011fer a\u011f\u0131r hastal\u0131klar\u0131 da tetikledi\u011fini hat\u0131rlat\u0131yor. \u00d6rne\u011fin; Hepatit vir\u00fcsleri karaci\u011fer sirozuna, mide mikrobu (H. pylori) peptik \u00fclsere ve gastrointestinal kanamalara, EBV vir\u00fcs\u00fc ise ba\u011f\u0131\u015f\u0131kl\u0131k sistemini vurarak Multipl Skleroz (MS) ve Lupus (SLE) gibi kronik hastal\u0131klara yol a\u00e7\u0131yor.<\/p>\n\n\n

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Enfeksiyon etkenine, BM co\u011frafi alt b\u00f6lgesine ve cinsiyete g\u00f6re 2024 y\u0131l\u0131nda 100.000 ki\u015fi-y\u0131l ba\u015f\u0131na enfeksiyon kaynakl\u0131 kanserlerin ya\u015f s\u0131n\u0131r\u0131 indeksi.<\/figcaption><\/figure><\/div>\n\n\n

Avustralya mucizesi ve k\u00fcresel engeller<\/h3>\n\n\n\n

Bula\u015f\u0131c\u0131 mikroplar, d\u00fcnyada ya\u015fam tarz\u0131 de\u011fi\u015ftirilerek \u00f6nlenebilecek en b\u00fcy\u00fck kanser riski. Neyse ki t\u0131p d\u00fcnyas\u0131n\u0131n elinde a\u015f\u0131lar, tarama y\u00f6ntemleri ve g\u00fcvenli enjeksiyon uygulamalar\u0131 gibi \u00e7ok g\u00fc\u00e7l\u00fc silahlar var.
Enfeksiyon kaynakl\u0131 kanserleri \u00f6nlemenin d\u00fcnyadaki en ba\u015far\u0131l\u0131 \u00f6rne\u011fi Avustralya’da ya\u015fand\u0131. \u00dclkede 2007 y\u0131l\u0131nda ba\u015flat\u0131lan HPV a\u015f\u0131s\u0131 program\u0131 sayesinde enfeksiyonlar %90 oran\u0131nda azald\u0131. Bu muazzam ba\u015far\u0131yla Avustralya, 2035 y\u0131l\u0131na kadar rahim a\u011fz\u0131 kanserini tamamen silme yolunda ilerliyor.<\/p>\n\n\n\n

K\u00fcresel adaletsizlik, \u00e7\u00f6z\u00fcm var ama para yok<\/strong><\/p>\n\n\n\n

IARC’nin en ac\u0131 tespiti ise k\u00fcresel sa\u011fl\u0131k adaletsizli\u011fi \u00fczerine. Enfeksiyon kaynakl\u0131 kanser vakalar\u0131n\u0131n yakla\u015f\u0131k %75’i d\u00fc\u015f\u00fck ve orta gelirli \u00fclkelerde k\u00fcmeleniyor. DS\u00d6’n\u00fcn tek dozluk HPV a\u015f\u0131 program\u0131 onay\u0131 maliyetleri d\u00fc\u015f\u00fcrse de, yoksul \u00fclkelerde a\u015f\u0131lama kapsam\u0131 h\u00e2l\u00e2 \u00e7ok yetersiz. Mide kanserinin ba\u015f sorumlusu olan H. pylori bakterisine kar\u015f\u0131 uygulanan endoskopik kitlesel taramalar \u00e7ok pahal\u0131 oldu\u011fundan yoksul \u00fclkelerde hayata ge\u00e7irilemiyor. Kaposi sarkomu veya EBV i\u00e7in ise hen\u00fcz etkili bir a\u015f\u0131 geli\u015ftirilebilmi\u015f de\u011fil.<\/p>\n\n\n

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Birle\u015fmi\u015f Milletler co\u011frafi alt b\u00f6lgelerine ve kanser t\u00fcrlerine g\u00f6re 2024 y\u0131l\u0131nda EBV’ye atfedilebilen kanser vakalar\u0131n\u0131n mutlak say\u0131lar\u0131 ve oranlar\u0131.<\/figcaption><\/figure><\/div>\n\n\n

Verilerin arkas\u0131ndaki dev ara\u015ft\u0131rma<\/h3>\n\n\n\n

Bu \u00e7arp\u0131c\u0131 sonu\u00e7lar, d\u00fcnya genelindeki 460 n\u00fcfus tabanl\u0131 kanser kayd\u0131n\u0131 inceleyen devasa bir metodolojiye ve en g\u00fcncel GLOBOCAN verilerine dayan\u0131yor. Ancak uzmanlar insani bir itirafta da bulunuyor: D\u00fcnyadaki y\u00fcksek kaliteli kanser kay\u0131t sistemleri k\u00fcresel n\u00fcfusun yaln\u0131zca %19’unu, krizin kalbi olan Afrika n\u00fcfusunun ise sadece %2’sini kaps\u0131yor. Bu durum, yoksul b\u00f6lgelerdeki ger\u00e7ek kanser bilan\u00e7osunun tahmin edilenlerin \u00e7ok daha \u00fczerinde olabilece\u011fini g\u00f6steriyor.<\/p>\n\n\n\n

2050 kabusu zaman daral\u0131yor<\/strong><\/p>\n\n\n\n

D\u00fcnya n\u00fcfusunun h\u0131zla ya\u015flanmas\u0131 ve b\u00fcy\u00fcmesi nedeniyle, 2024 y\u0131l\u0131nda 20 milyon olan yeni kanser vaka say\u0131s\u0131n\u0131n 2050 y\u0131l\u0131nda 35 milyona f\u0131rlayaca\u011f\u0131 tahmin ediliyor. Bu korkun\u00e7 art\u0131\u015f\u0131n yarataca\u011f\u0131 amans\u0131z ekonomik ve sosyal maliyetleri engellemenin tek yolu, bug\u00fcnden \u00f6nleyici t\u0131bba yat\u0131r\u0131m yapmak. Kanserle m\u00fccadele; toplumsal \u00f6nyarg\u0131lar\u0131n k\u0131r\u0131ld\u0131\u011f\u0131, yabanc\u0131 yard\u0131m fonlar\u0131n\u0131n kesilmedi\u011fi ve adil sa\u011fl\u0131k politikalar\u0131n\u0131n uyguland\u0131\u011f\u0131 k\u00fcresel bir seferberlik gerektiriyor.<\/p>\n\n\n\n

Kaynak:<\/em> Global burden of cancer attributable to infections in 2024: a worldwide incidence analysis, Harriet Rumgay, Damien Georges, Yue Huang, Mayo Hirabayashi, Richa Shah, Catherine de Martel vd., The Lancet Oncology<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Kanser risk fakt\u00f6rleri denildi\u011finde \u00e7o\u011fumuzun akl\u0131na ilk olarak sigara, g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 veya genetik yatk\u0131nl\u0131k gelir. Kanser risk fakt\u00f6rleri denildi\u011finde \u00e7o\u011fumuzun akl\u0131na ilk olarak sigara, g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 veya genetik yatk\u0131nl\u0131k gelir. Ancak t\u0131p d\u00fcnyas\u0131ndan gelen son veriler, gizli bir tehlikeyi g\u00f6zler \u00f6n\u00fcne seriyor. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc\u2019ne (DS\u00d6) ba\u011fl\u0131 Uluslararas\u0131 Kanser Ara\u015ft\u0131rma Ajans\u0131’n\u0131n (IARC) yapt\u0131\u011f\u0131 yeni bir […]<\/p>\n","protected":false},"author":13981,"featured_media":172390,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"kanser","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Kanser risk fakt\u00f6rleri denildi\u011finde \u00e7o\u011fumuzun akl\u0131na ilk olarak sigara, g\u00fcne\u015f \u0131\u015f\u0131\u011f\u0131 veya genetik yatk\u0131nl\u0131k gelir.","_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":"","_yoast_wpseo_focuskw_text_input":""},"categories":[70,8138,19],"tags":[825,809,7356,12951,7222,12949,12948,12945,512,12950,12954,12953,12952,12946,574],"yoast_head":"\nKanser Vakalar\u0131n\u0131n Sekizde Biri Enfeksiyonlardan Kaynaklan\u0131yor - 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