{"id":172553,"date":"2026-10-07T09:00:14","date_gmt":"2026-10-07T06:00:14","guid":{"rendered":"https:\/\/epochtimestr.com\/?p=172553"},"modified":"2026-10-07T09:00:16","modified_gmt":"2026-10-07T06:00:16","slug":"2026-nobel-tip-odulu-optogenetik-teknolojisine-gitti","status":"publish","type":"post","link":"https:\/\/epochtimestr.com\/index.php\/2026-nobel-tip-odulu-optogenetik-teknolojisine-gitti","title":{"rendered":"2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc Optogenetik Teknolojisine Gitti"},"content":{"rendered":"
\n
\"2026
2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc optogenetik teknolojisine gitti. (G\u00f6rsel: Nobel Prize web)<\/figcaption><\/figure><\/div>\n\n\n

2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc optogenetik teknolojisine gitti. I\u015f\u0131kla beyni kontrol eden \u00fc\u00e7 bilim insan\u0131 Karl Deisseroth, Peter Hegemann ve Georg Nagel b\u00fcy\u00fck \u00f6d\u00fcl\u00fcn sahibi oldu.<\/h2>\n\n\n\n

Sinir h\u00fccrelerinin faaliyetlerini \u0131\u015f\u0131k kullanarak kontrol etmeyi sa\u011flayan “optogenetik” y\u00f6nteminin geli\u015ftirilmesine katk\u0131 sunan Karl Deisseroth, Peter Hegemann ve Georg Nagel, 2026 Nobel<\/a> Fizyoloji veya T\u0131p \u00d6d\u00fcl\u00fcn\u00fcn sahibi oldu. Karolinska Enstit\u00fcs\u00fc Nobel Kurulu taraf\u0131ndan yap\u0131lan a\u00e7\u0131klamada, 12 milyon \u0130sve\u00e7 kronu (yakla\u015f\u0131k 1,1 milyon ABD dolar\u0131) tutar\u0131ndaki b\u00fcy\u00fck \u00f6d\u00fcl\u00fcn, \u00fc\u00e7 bilim insan\u0131 aras\u0131nda e\u015fit olarak payla\u015ft\u0131r\u0131laca\u011f\u0131 belirtildi.<\/p>\n\n\n\n

Nobel Komitesi Ba\u015fkan\u0131 Per Svenningsson, \u00f6d\u00fcl gerek\u00e7esini a\u00e7\u0131klarken, “Optogenetik, bir zamanlar sadece hayalini kurabildi\u011fimiz bir \u015fekilde beyni<\/a> haritalama f\u0131rsatlar\u0131 sunuyor” ifadelerini kulland\u0131.<\/p>\n\n\n\n

Gizemli beyin haritas\u0131nda yeni d\u00f6nem<\/strong><\/p>\n\n\n\n

\u0130nsan beyninin an\u0131lar\u0131 nas\u0131l \u015fekillendirdi\u011fi, duygular\u0131 ve davran\u0131\u015flar\u0131 nas\u0131l y\u00f6netti\u011fi uzun y\u0131llar boyunca t\u0131p d\u00fcnyas\u0131n\u0131n en b\u00fcy\u00fck bilinmeyenlerinden biri olarak kald\u0131. 20. y\u00fczy\u0131ldaki geleneksel y\u00f6ntemler, beyin h\u00fccreleri aras\u0131ndaki nedensel ba\u011flar\u0131 kan\u0131tlamakta yetersiz kal\u0131yor ve geriye eksik bir harita b\u0131rak\u0131yordu. Bu y\u0131l \u00f6d\u00fcl kazanan ara\u015ft\u0131rmac\u0131lar\u0131n geli\u015ftirdi\u011fi y\u00f6ntem, sinirbilimde kelimenin tam anlam\u0131yla yeni bir d\u00f6nemin temellerini att\u0131.<\/p>\n\n\n\n

I\u015f\u0131k arayan algler ilham oldu<\/h3>\n\n\n\n

Ke\u015fif s\u00fcreci, tek h\u00fccreli bir ye\u015fil alg t\u00fcr\u00fc olan Chlamydomonas’\u0131n fotosentez yapabilmek i\u00e7in \u0131\u015f\u0131k kayna\u011f\u0131na do\u011fru nas\u0131l y\u00f6nlendi\u011finin merak edilmesiyle ba\u015flad\u0131. 2000’li y\u0131llar\u0131n ba\u015f\u0131nda Alman ara\u015ft\u0131rmac\u0131lar Peter Hegemann ve Georg Nagel, bu algin h\u00fccre zar\u0131nda benzersiz \u00f6zelliklere sahip, \u0131\u015f\u0131\u011fa duyarl\u0131 bir protein olan “kanalrodopsin”i ke\u015ffettiler. Mavi \u0131\u015f\u0131kla ayd\u0131nlat\u0131ld\u0131\u011f\u0131nda i\u00e7inden bir kanal a\u00e7an bu protein, h\u00fccre i\u00e7ine y\u00fckl\u00fc iyonlar\u0131n akmas\u0131n\u0131 sa\u011flayarak elektriksel bir d\u00fcrt\u00fc olu\u015fturuyordu.<\/p>\n\n\n\n

Canl\u0131 beyninde ilk deney 2007’de yap\u0131ld\u0131<\/strong><\/p>\n\n\n\n

ABD’li bilim insan\u0131 Karl Deisseroth ise bu ke\u015ffi sinirbilime uyarlayarak \u00e7\u0131\u011f\u0131r a\u00e7an bir ad\u0131ma imza att\u0131. Deisseroth, alglerden al\u0131nan bu geni laboratuvar ortam\u0131nda memeli sinir h\u00fccrelerine ba\u015far\u0131yla yerle\u015ftirdi ve h\u00fccreleri mavi \u0131\u015f\u0131kla uyararak yapay bir sinir sinyali tetiklemeyi ba\u015fard\u0131. 2005 y\u0131l\u0131nda yay\u0131mlanan bu b\u00fcy\u00fck geli\u015fmeden iki y\u0131l sonra, sinir sistemi i\u00e7in geli\u015ftirilen bu \u0131\u015f\u0131kla kontrol anahtar\u0131 canl\u0131 farelerin beyinlerinde de ba\u015far\u0131yla \u00e7al\u0131\u015ft\u0131r\u0131ld\u0131.<\/p>\n\n\n\n

K\u00f6rl\u00fck ve Psikiyatrik hastal\u0131klara umut \u0131\u015f\u0131\u011f\u0131<\/strong><\/p>\n\n\n\n

G\u00fcn\u00fcm\u00fczde “optogenetik” olarak adland\u0131r\u0131lan bu y\u00f6ntem, d\u00fcnya genelinde binlerce laboratuvarda Parkinson, depresyon, ba\u011f\u0131ml\u0131l\u0131k, epilepsi ve \u015fizofreni gibi pek co\u011frafi, n\u00f6rolojik ve psikiyatrik bozuklu\u011fun ard\u0131ndaki hatal\u0131 sinir devrelerini ortaya \u00e7\u0131karmak i\u00e7in temel bir ara\u00e7 olarak kullan\u0131l\u0131yor. Klinik t\u0131pta ise ara\u015ft\u0131rmac\u0131lar, retina hasar\u0131 olan g\u00f6rme engelli bireylerin g\u00f6rme yetisini geri kazand\u0131rmak ve i\u015fitme engelliler i\u00e7in yeni nesil optogenetik i\u015fitme cihazlar\u0131 (koklear implantlar) geli\u015ftirmek amac\u0131yla bu y\u00f6ntemden yararlan\u0131yor.<\/p>\n\n\n\n

\u00d6d\u00fcl sahibi bilim insanlar\u0131 kimlerdir?<\/h3>\n\n\n\n

Prof. Dr. Karl Deisseroth (ABD):<\/em><\/strong> 1971 do\u011fumlu. Doktora ve t\u0131p doktoru derecelerini Stanford \u00dcniversitesi’nden ald\u0131. Halen Stanford \u00dcniversitesi ve Howard Hughes T\u0131p Enstit\u00fcs\u00fc’nde Biyom\u00fchendislik ile Psikiyatri alanlar\u0131nda profes\u00f6rl\u00fck yapmaktad\u0131r.<\/p>\n\n\n\n

Prof. Dr. Peter Hegemann (Almanya): <\/em><\/strong>1954 do\u011fumlu. Doktoras\u0131n\u0131 Max Planck Biyokimya Enstit\u00fcs\u00fc’nde tamamlad\u0131. \u00c7al\u0131\u015fmalar\u0131n\u0131 Berlin Humboldt \u00dcniversitesi’nde Deneysel Biyofizik Profes\u00f6r\u00fc olarak s\u00fcrd\u00fcrmektedir.<\/p>\n\n\n\n

Prof. Dr. Georg Nagel (Almanya): <\/em><\/strong>1953 do\u011fumlu. Doktoras\u0131n\u0131 Frankfurt’taki Max Planck Biyofizik Enstit\u00fcs\u00fc’nde tamamlad\u0131. 2004 y\u0131l\u0131ndan beri W\u00fcrzburg \u00dcniversitesi’nde Molek\u00fcler Bitki Fizyolojisi Profes\u00f6r\u00fc olarak g\u00f6rev yapmaktad\u0131r.<\/p>\n\n\n\n

Vasiyetinde t\u0131p ara\u015ft\u0131rmalar\u0131na \u00f6zel bir \u00f6nem atfeden Alfred Nobel’in an\u0131s\u0131na verilen ve t\u0131p d\u00fcnyas\u0131n\u0131n en prestijli \u00f6d\u00fcl\u00fc kabul edilen Nobel T\u0131p \u00d6d\u00fcl\u00fc, ge\u00e7ti\u011fimiz y\u0131l (2025) ba\u011f\u0131\u015f\u0131kl\u0131k<\/a> sisteminin kontrol mekanizmalar\u0131 \u00fczerine yapt\u0131klar\u0131 \u00e7al\u0131\u015fmalarla Mary Brunkow, Fred Ramsdell ve Shimon Sakaguchi’ye verilmi\u015fti.<\/p>\n","protected":false},"excerpt":{"rendered":"

2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc optogenetik teknolojisine gitti. I\u015f\u0131kla beyni kontrol eden \u00fc\u00e7 bilim insan\u0131 Karl Deisseroth, Peter Hegemann ve Georg Nagel b\u00fcy\u00fck \u00f6d\u00fcl\u00fcn sahibi oldu. Sinir h\u00fccrelerinin faaliyetlerini \u0131\u015f\u0131k kullanarak kontrol etmeyi sa\u011flayan “optogenetik” y\u00f6nteminin geli\u015ftirilmesine katk\u0131 sunan Karl Deisseroth, Peter Hegemann ve Georg Nagel, 2026 Nobel Fizyoloji veya T\u0131p \u00d6d\u00fcl\u00fcn\u00fcn sahibi oldu. Karolinska Enstit\u00fcs\u00fc […]<\/p>\n","protected":false},"author":12791,"featured_media":172554,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"2026 Nobel T\u0131p","_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc optogenetik teknolojisine gitti. I\u015f\u0131kla beyni kontrol eden \u00fc\u00e7 bilim insan\u0131 b\u00fcy\u00fck \u00f6d\u00fcl\u00fcn sahibi oldu.","_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_forum_subforum_count":0,"footnotes":"","_yoast_wpseo_focuskw_text_input":""},"categories":[70,1,8138,19],"tags":[13034,407,708,365,13035,13033,13031,13032],"yoast_head":"\n2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc Optogenetik Teknolojisine Gitti - The Epoch Times TR<\/title>\n<meta name=\"description\" content=\"2026 Nobel T\u0131p \u00d6d\u00fcl\u00fc optogenetik teknolojisine gitti. 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